Leading the way in Hep C treatment

HARVONI is a prescription medicine used with or without ribavirin to treat chronic (lasting a long time) hepatitis C genotype 1, 4, 5 or 6 infection. It is not known if HARVONI is safe and effective in children under 18 years of age.

In the past, treatment regimens for Hep C genotype 1 were challenging. They often included multiple separate medicines and complicated dosing, and were frequently difficult to tolerate.

Now, there’s HARVONI.

HARVONI transformed Hep C treatment as the first cure that's one pill, once a day. There's no interferon, no complex regimens.

In clinical studies, 96-99% of patients with Hep C genotype 1 who had no prior treatment were cured with just 12 weeks of therapy.*

If you don't have Hep C genotype 1, 4, 5, or 6, learn about another treatment option that may be right for you.

Cure means the Hep C virus is not detected in the blood when measured three months after treatment is completed.

*In a study of 865 patients with genotype 1 Hep C and no prior Hep C treatment, with or without advanced liver disease (cirrhosis), 99% (210 out of 213) of those who received HARVONI once daily for 12 weeks were cured. In a separate study of 647 patients with genotype 1 Hep C, with no prior Hep C treatment and without cirrhosis, 96% (208 out of 216) of those who received HARVONI once daily for 12 weeks were cured. These studies did not include patients with liver failure or those who have had a liver transplant.

Have you been treated for Hep C before? See study data for Hep C genotype 1 patients with prior Hep C treatment.

See full HARVONI clinical study results

Thinking about treatment with HARVONI? Sign up for Onward™ and get free step-by-step guidance to help you get started.

HARVONI is a prescription medicine used with or without ribavirin to treat chronic (lasting a long time) hepatitis C genotype 1, 4, 5 or 6 infection. It is not known if HARVONI is safe and effective in children under 18 years of age.

Important Safety Information

What should I tell my healthcare provider before taking HARVONI?

  • If you have: liver problems other than hepatitis C infection, or have had a liver transplant; severe kidney problems or are on dialysis; HIV, or any other medical condition; or if you are pregnant or breastfeeding or plan to become pregnant or breastfeed. It is not known if HARVONI will harm your unborn baby or pass into your breast milk. If you take HARVONI with ribavirin, you should also read the ribavirin Medication Guide for important pregnancy-related information.

Continued below

A clear step forward in Hep C treatment

HARVONI revolutionized Hep C treatment by combining two drugs (ledipasvir and sofosbuvir) into one pill. It works by targeting certain proteins in the Hep C virus to keep it from reproducing in the body. HARVONI is powered by sofosbuvir, a medicine that is transforming Hep C treatment and now makes possible a clear evolution from past regimens.

Evolution of Hep C Genotype 1 Therapy (Select Treatments)

  • Peginterferon
    + ribavirin 2001
    Up to 6 pills per day 1 shot per week
  • Protease inhibitors
    + peginterferon
    + ribavirin 2011
    Up to 18 pills per day 1 shot per week
  • Sofosbuvir
    + peginterferon
    + ribavirin 2013
    Up to 7 pills per day 1 shot per week
  • HARVONI
    ledipasvir/sofosbuvir 2014
    1 pill per day*

*For the majority of patients

Important Safety Information

What should I tell my healthcare provider before taking HARVONI? (continued)

  • Tell your healthcare provider and pharmacist about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. HARVONI and certain other medicines may affect each other, or may cause side effects. Tell your healthcare provider if you take any medicines containing tenofovir disoproxil fumarate (ATRIPLA®, COMPLERA®, STRIBILD®, TRUVADA®, VIREAD®).

Continued below

Knowing your Hep C genotype is important

Just as there are different blood types, there are also different types of Hep C, called genotypes. There are 6 main genotypes, numbered 1 through 6. The most common type in the U.S. is genotype 1.

Approximately 75% in the US with Hep C have Genotype 1

If you don't have Hep C genotype 1, 4, 5, or 6, learn about another treatment option that may be right for you.

Often people don't know the genotype of Hep C that they have. But knowing your type of Hep C is important because it helps your Hep C Specialist choose the right treatment for you. It can also affect the length of your treatment. To learn more about genotypes, reach out to your Hep C Specialist.

Important Safety Information

What are the possible side effects of HARVONI?

  • HARVONI, when taken with amiodarone (Cordarone®, Nexterone®, Pacerone®), a medicine used to treat certain heart problems, may cause serious side effects, including slow heart rate, which in some cases has led to death or the need for a pacemaker. Get medical help right away if you take amiodarone with HARVONI and get any of the following symptoms: fainting or near-fainting, dizziness or lightheadedness, not feeling well, weakness, extreme tiredness, shortness of breath, chest pains, confusion, or memory problems.
  • The most common side effects of HARVONI include tiredness, headache and weakness.
SEE MORE

HARVONI is a prescription medicine used with or without ribavirin to treat chronic (lasting a long time) hepatitis C genotype 1, 4, 5 or 6 infection. It is not known if HARVONI is safe and effective in children under 18 years of age.

Important Safety Information

What should I tell my healthcare provider before taking HARVONI?

  • If you have: liver problems other than hepatitis C infection, or have had a liver transplant; severe kidney problems or are on dialysis; HIV, or any other medical condition; or if you are pregnant or breastfeeding or plan to become pregnant or breastfeed. It is not known if HARVONI will harm your unborn baby or pass into your breast milk. If you take HARVONI with ribavirin, you should also read the ribavirin Medication Guide for important pregnancy-related information.
  • Tell your healthcare provider and pharmacist about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. HARVONI and certain other medicines may affect each other, or may cause side effects. Tell your healthcare provider if you take any medicines containing tenofovir disoproxil fumarate (ATRIPLA®, COMPLERA®, STRIBILD®, TRUVADA®, VIREAD®).

What are the possible side effects of HARVONI?

  • HARVONI, when taken with amiodarone (Cordarone®, Nexterone®, Pacerone®), a medicine used to treat certain heart problems, may cause serious side effects, including slow heart rate, which in some cases has led to death or the need for a pacemaker. Get medical help right away if you take amiodarone with HARVONI and get any of the following symptoms: fainting or near-fainting, dizziness or lightheadedness, not feeling well, weakness, extreme tiredness, shortness of breath, chest pains, confusion, or memory problems.
  • The most common side effects of HARVONI include tiredness, headache and weakness.
SEE MORE

Important Safety Information

What should I tell my healthcare provider before taking HARVONI?

  • If you have: liver problems other than hepatitis C infection, or have had a liver transplant; severe kidney problems or are on dialysis; HIV, or any other medical condition; or if you are pregnant or breastfeeding or plan to become pregnant or breastfeed. It is not known if HARVONI will harm your unborn baby or pass into your breast milk. If you take HARVONI with ribavirin, you should also read the ribavirin Medication Guide for important pregnancy-related information.
  • Tell your healthcare provider and pharmacist about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. HARVONI and certain other medicines may affect each other, or may cause side effects. Tell your healthcare provider if you take any medicines containing tenofovir disoproxil fumarate (ATRIPLA®, COMPLERA®, STRIBILD®, TRUVADA®, VIREAD®).

What are the possible side effects of HARVONI?

  • HARVONI, when taken with amiodarone (Cordarone®, Nexterone®, Pacerone®), a medicine used to treat certain heart problems, may cause serious side effects, including slow heart rate, which in some cases has led to death or the need for a pacemaker. Get medical help right away if you take amiodarone with HARVONI and get any of the following symptoms: fainting or near-fainting, dizziness or lightheadedness, not feeling well, weakness, extreme tiredness, shortness of breath, chest pains, confusion, or memory problems.
  • The most common side effects of HARVONI include tiredness, headache and weakness.

HARVONI is a prescription medicine used with or without ribavirin to treat chronic (lasting a long time) hepatitis C genotype 1, 4, 5 or 6 infection. It is not known if HARVONI is safe and effective in children under 18 years of age.

Hear from people who already put Hep C behind them